Born in Muharraq in the palace of her paternal grandfather, the late Shaikh Mohammed bin Isa bin Ali Al Khalifa. She was brought up in Riffa in the care of her maternal grandfather, Shaikh Salman bin Hamad Al Khalifa. Her mother Shaikha Fatima bint Salman Al Khalifa is the eldest daughter of His Highness Shaikh Salman bin Hamad Al Khalifa, the former Ruler of Bahrain.
Her Royal Highness got married to His Majesty King Hamad bin Isa Al Khalifa in 1968. They have four children (three sons and one daughter). The eldest is His Royal Highness the Crown Prince Deputy Supreme Commander, Prince Salman bin Hamad Al Khalifa, who was born in October 1969.